X-chromosomal inactivation analysis of uterine leiomyomas reveals a common clonal origin of different tumor nodules in some multiple leiomyomas
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چکیده
منابع مشابه
X-chromosomal inactivation analysis of uterine leiomyomas reveals a common clonal origin of different tumor nodules in some multiple leiomyomas.
Uterine leiomyomas were shown to be clonal lesions, but the relationship among different tumor nodules in multiple uterine leiomyomas remains unresolved. In this study, X-chromosomal inactivation patterns of these tumor nodules were shown by allelic polymorphism analysis through polymerase-chain reaction at the phosphoglycerate kinase and androgen receptor loci following pretreatment with the m...
متن کاملIndependent clonal origin of multiple uterine leiomyomas that was determined by X chromosome inactivation and microsatellite analysis.
OBJECTIVE In an attempt to clarify the clonality and genetic relationships that are involved in the tumorigenesis of uterine leiomyomas, we used a total of 43 multiple leiomyomas from 14 patients and analyzed the allelic status with 15 microsatellite markers and X chromosome inactivation analysis. STUDY DESIGN We have used a set of 15 microsatellite polymorphism markers mapped on 3q, 7p, 11, ...
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ژورنال
عنوان ژورنال: International Journal of Oncology
سال: 2007
ISSN: 1019-6439,1791-2423
DOI: 10.3892/ijo.31.6.1379